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According to recent market research, the vaccines market is expected to grow at a compound annual rate of 14.7% for the forecast period of 2020-2026 (1), the growth of which has been accelerated by the recent COVID-19 pandemic. Durability of glass vials at very low temperatures and permeability of plastic vials has complicated the packaging decisions as well." Since the beginning of the pandemic, the bio/pharma industry has been under pressure to produce stable formulations for effective vaccines in accelerated timescales, Blouet asserts. [...]the drive for a COVID-19 vaccine has occurred during a period of increased basic scientific understanding, such as in genomics and structural biology, supporting a new wave of vaccine development and production, she says. According to Phadnis, in addition to single-use technologies, automation for high throughput and robust analytical assays are necessary for rapid turnover during development and manufacturing of vaccines.
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[...]findings of this rapid review suggest that the state of the telehealth and RPM scientific literature is in its infancy. Health Information Management Systems Society (HIMSS);the American Nurses Association (ANA);Johnson & Johnson;Society of Nurse Scientists, Innovators, Entrepreneurs and Leaders (SONSIEL);and the American Organization of Nurse Leaders (AONL). [...]the Joanna Briggs Institute (JBI) Critical Appraisal Tools (2017) were used to appraise the quality (i.e., low, moderate, high) of each article from the traditional literature. [View full size] Data extraction, reported in Table 2. lists these descriptors for each study: a description of the Innovation, study design, conceptual model, sample, sampling strategy, setting, data analysis or analytics techniques, concept deployed, quality of the research and the role of the nurse-author(s).
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With everything from real-time release testing to automated regulatory audit trail software continuing to gain prominence in the sector, an in-depth look toward the future of dissolution testing is needed for those seeking comprehensive understanding of the industry. [...]things like remote instrument monitoring, maintenance, validation, and possibly repair, software as a service, etc. start becoming subjects of discussion. Together with the move to software control discussed previously, this may make these concepts palatable and applicable to pharma the way they are accepted as de facto in many other industries.
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Digital transformation, which significantly impacts our personal, social, and economic spheres of life, is regarded by many as the most significant development of recent decades. In an industrial context, based on a systematic literature review of 262 papers selected from the ProQuest database, using the methodology of David and Han, this paper discusses Industry 4.0 technologies as the key drivers and/or enablers of digital transformation for business practices, models, processes, and routines in the current digital age. After carrying out a systematic literature review considering key Industry 4.0 technologies, we discuss the individual and collective ways in which competitiveness in contemporary organizations and institutions is enhanced. Specifically, we discuss how these technologies contribute as antecedents, drivers, and enablers of environmental and social sustainability, corporate growth and diversification, reshoring, mass customization, B2B cooperation, supply chain integration, Lean Six Sigma, quality of governance, innovations, and knowledge related to dealing with challenges arising from global pandemics such as COVID-19. A few challenges related to the effective adoption and implementation of Industry 4.0 are also highlighted, along with some suggestions to overcome them.
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PurposeVirtual and augmented reality solutions in medicine are generally applied in communication, training, simulation and therapy. However, like most new digital developments, these technologies face a large number of institutional barriers that are inherent to the medical sector.Design/methodology/approachFollowing Richard Scott's view on institutions and organizations, a multiple case study is used to analyze regulatory, normative and cultural-cognitive institutional pillars in the medical industry.FindingsThe results of the study demonstrate that (1) the regulatory pillar inhibits the advancement of new technologies in the approach to treatment, regulation of patient data, educational processes for medical staff, and information and financial flows;(2) the number of barriers increases based on the solution's level of disruption and the number of variable conventional procedures;(3) trust between participants in the medical industry plays an important role in introducing new technologies;(4) new participants need to address certain pillars depending on the area of application.Originality/valueThe authors discuss top-down and bottom-up approaches for overcoming institutional barriers when implementing augmented and virtual reality solutions for companies focusing on the medical market.
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Jim Reilly, VP of Clinical Strategy, Veeva Systems Reilly has led teams responsible for sales and delivery of clinical data standards and regulatory technologies at Accenture (formerly as part Octagon Research Solutions), and has extensive consulting experience from his time at Octagon Research, as well as HighPoint Solutions, where he led business process improvement and technology selection programs in clinical and regulatory operations at a number of large pharmaceutical organizations. [...]sites rely on sponsors and CROs to provide technology for managing trial activities and collaborating during a study. The resulting gains in efficiency, visibility, and quality will enable trials to run faster, simplify data sharing and collaboration, and ultimately, accelerate delivery of breakthrough drugs and treatments to the market amidst a more complex clinical trial environment." Some companies have clinical project leads, clinical trial leads, lead clinical research associates (CRAs), but ultimately, what a clinical operations makeover would truly look like depends on the size of the company and what the expectations are around the ClinOps role as well as the needs of the organization.
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The industry has responded by incorporating remote monitoring techniques and fast-tracking the use of hybrid and decentralized clinical trial (DCT) models, at a pace never seen before. Interactive voice response systems (IVRS) and electronic data capture (EDC) solutions were introduced in the late 1980s and early '90s but these are only now reaching wide adoption by sponsors and contract research organizations (CROs).1 Electronic patient-reported outcomes (ePRO), electronic clinical outcomes assessment (eCOA), and eSource technologies, while introduced in the mid to late '90s, have yet to achieve wide adoption.2 This pattern holds true for risk-based monitoring (RBM), digital health outcomes, and other innovative approaches and solutions. [...]the survey focused on opportunities for accelerating the innovation adoption process. A variety of roles were also represented, including professionals from clinical operations (46%);clinical development (9%);innovation management (17%);data science & data management (10%);information technology (3%);and 15% from other roles. [...]14.5% of respondents were part of a centralized or dedicated innovation group, whereas the majority (85.5%) worked outside of such an innovation group. [...]responses reflect a broad cross-section of views and perspectives from which to learn more about how the biopharmaceutical industry approaches the innovation adoption process, what gets in the way, and how organizations and the industry more broadly can accelerate new technologies and innovations.
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Purpose We hope to provoke a conversation about preparing students for an uncertain future that unforeseeable technological innovations will transform in ways we cannot predict. The unprecedented disruption caused by the COVID-19 pandemic makes this an opportune time to reconsider all dimensions of education. Design/Approach/Methods We present information on how technology is transforming virtually every aspect of our lives and the threats we face from social media, climate change, and growing inequality. We then analyze the adequacy of proposals for teaching new skills, such as 21st-Century Skills, to prepare students for a world of work that is changing at warp speed. Findings Despite harbingers of a radically different future, most schools continue to operate much as they have for centuries, providing a one-size-fits-all education. Technology now enables an unprecedented degree of personalization. We can tailor learning opportunities to individual students' interests, talents, and potential with teachers serving as guides, resources, and critical friends. The Internet afford a cornucopia of learning opportunities—online courses, international experts, global collaborations, accessible databases, and libraries. Learning can occur virtually anywhere. Originality/Value The future depends on decisions we are making today about education. The value of this article is that we call for rethinking every component of education rather than considering each element independently.
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Syringe innovations also increase patient and caregiver safety and efficiency and reduce waste of product and packaging materials. "Since it is already packaged ready for the injection, the prefilled syringe saves time and avoids unneeded handling prior to the actual application, minimizing the risk of the injection errors, dilution errors, or non-sterility issues [that are a risk in] multi-dose containers," explains Wenzel Novak, global senior director of business development at Gerresheimer Medical Systems. [...]the advent of a silicone-free design, "Pharmaceutical manufacturers seeking to avoid silicone-induced aggregation and sub-visible particles have had to choose vials even when they wanted to offer other delivery options," said Christiane Gumera, product specialist at W.L. Gore & Associates. [...]automation decreases labour requirements, diminishes the difficulties of working in a cleanroom with full personal protective equipment, and reduces the likelihood of repetitive motion injuries." [...]information technology systems supporting serialization can communicate with the customer's system to ensure that the serial numbers applied are unique and traceable across the network of product manufacturing sites the customer may be using."
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In this concluding chapter, we draw together the various contributions presented in this volume, discuss the broader implications of our findings, and reflect on how this builds upon Willy Brown's work. The chapter examines how the patchwork of rules has been altered by new and emerging challenges, such as the COVID-19 pandemic, the rise of global supply chains and new forms of business. We return to the central objective of this volume of identifying and analysing the viability of various institutions for addressing these challenges and discuss how these might form the basis of a new web of rules for protecting labour standards in the future. © 2023 by Emerald Publishing Limited. All rights reserved.
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This article uses data from several publicly available databases to show that the distribution of intellectual property for frontier technologies, including those useful for sustainable development, is very highly skewed in favor of a handful of developed countries. The intellectual property rights (IPR) regime as it exists does not optimize the global flow of technology and know-how for the attainment of the sustainable development goals and is in need of updating. Some features of the Fourth Industrial Revolution imply that the current system of patents is even more in need of reform than before. COVID-19 vaccines and therapies and the vast inequality in access to these has highlighted the costs of inaction. We recommend several policy changes for the international IPR regime. Broadly, these fall into three categories: allowing greater flexibility for developing countries, reassessing the appropriateness of patents for technologies that may be considered public goods, and closing loopholes that allow for unreasonable intellectual property protections.
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Advances in tissue engineering, microfabrication, and biocompatible microfluidic chambers alongside the governmental (2) and regulatory (3) appetite to seek animal-free innovations in the drug development process has fuelled further interest and investment in this marketplace. According to market research, the global O°C market is forecast to be worth US$388 million (€354 million) by 2028 increasing from US$82 million (€75 million) in 2023, with a compound average growth of 36.4% from 2023 to 2028 (4). In March 2022, Lyon-based NETRI, attracted €8 million series A funding to help develop its novel high throughput (HT) compartmentalized microfluidic brain-on-a-chip and skin-on-a-chip technology for use by the pharma and cosmetic industry (15). Global Organ-onChip Market Size, Share, Trends, COVID-19 Impact and Growth Analysis ReportSegmented by Type (Heart-on-chip, Humanon-chip, Intestine-on-chip, Kidney-on-chip, Liver-on-chip and Lung-on-chip), Application and Region (North America, Europe, AsiaPacific, Latin America, Middle East and Africa)-Industry Forecast from 2023 to 2028.
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The people who work at companies that manufacture chromatography instruments and consumables are often well positioned to be aware of developments, needs, and trends that not everyone else sees, because they serve customers in a range of areas of focus and with diverse demands-such as academic researchers investigating fundamental aspects of separation science techniques, industrial analysts solving problems that they may not be allowed to talk about at conferences, or chemists working in government laboratories in areas like environmental research. Inaccurate data can be generated from variable, glass vial surface chemistries, which can lead to investigations or flawed decisions can be made from these results. The Reduced Surface Activity (RSA(tm)) Glass Technology was developed to address these issues, and to provide chemists with sample containers for LC-MS, MS, HPLC, GC, and CE that deliver reliable, consistent results by not adsorbing basic analytes, or adding metals to, or changing the pH of the diluent. The stringent RSA manufacturing processes are continued through to final contaminate-free packaging and quality control, where they are tested for adsorption, metal content, and residual materials.
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PurposeThis study investigates how customer experience mediates the relationship between online innovation and repurchase intention in the hotel industry in Ghana.Design/methodology/approachData was collected from 167 clients from a two-star hotel in Accra, the capital city of Ghana. Structural equation modelling was used to analyse the relationship between the variables.FindingsResults from the analysis indicate that online innovation positively leads to higher repurchase intentions and better customer experience, affirming that customer experience leads to repurchase intentions. Thus, while online innovation leads to repurchase intentions, the strength of this repurchase intention depends on customer experience. Therefore, customer experience mediates the relationship between online innovation and repurchase intention in the hotel industry.Research limitations/implicationsThis study addressed only the customer's point of view;future studies could investigate the subject from the managers and other stakeholders' point of view to get a holistic view. Also, the sample size could be improved, and the study could be conducted in other African countries for comparison purposes.Practical implicationsThe study shows that online innovation does not automatically lead to increased positive repurchase intention. Hotel managers must, therefore, enforce good customer experience for better profitability.Originality/valueAs far as the researchers know, limited studies have been conducted into how customer experience mediates online innovation and repurchase intention in the hotel industry in Ghana using structural equation modelling. This makes this research unique in Ghana. This study makes an original contribution by measuring the real effect of innovation on repurchase intentions in the hotel industry in Ghana.
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PurposeThere is an increasing interest in the supply chain's digitalization, yet the topic is still in the preliminary stages of academic research. The academic literature has no consensus and is still limited to research assessing the supply chain's digitalization of organizations. This study aims to explore the supply chain digitalization drivers to understand the emerging phenomena. More specifically, the authors devised from the literature the most common factors in assessing the readiness in scaling supply chain digitalization.Design/methodology/approachThis study followed a five-phased systematic literature review (SLR) methodology in this research: designing, analyzing, conducting, writing and assessing the quality of the review. The SLR is beneficial for justifying future research regardless of the complex process that requires dealing with high-level databases, information filtering and relevancies of the content. Through analysis of 347 titles and s and 40 full papers, the authors showed and discussed the supply chain digitalization: transformation factors.FindingsThe results generated three main themes: technology, people and processes. The study also generated ten subthemes/primary drivers for assessing the readiness for supply chain digitalization in organizations: IT infrastructure, cybersecurity systems, digitalization reskilling and upskilling, digitalization culture, top management support, digitalization and innovation strategy, integrated supply chain, digital innovation management, big data management and data analytics and government regulations. The importance of each factor was discussed, and future research agenda was presented.Research limitations/implicationsWhile the key drivers of the supply chain digitalization were identified, there is still a need to study the statistical correlation to confirm the interrelationships among factors. This study is also limited by the articles available in the databases and content extraction.Practical implicationsThis study supports decision-makers in understanding the critical drivers in digitalizing the supply chain. Once these factors are studied and comprehended, managers and decision-makers could better anticipate and allocate the proper resources to embark on the digitalization journey and make informed decisions.Originality/valueThe digitalization of the supply chain is more critical nowadays due to the global disruptions caused by the Coronavirus (COVID-19) pandemic and the surge of organizations moving toward the digital economy. There is a gap between the digital transformation pilot studies and implementation. The themes and factors unearthed in this study will serve as a foundation and guidelines for further theoretical research and practical implications.
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The Canadian labour market experienced a period of unprecedented turmoil following the onset of the COVID-19 pandemic. We analyze the main changes using standard labour force statistics and new data on job postings. Envisaging a phase of temporary severing of employment relationships followed by a phase of more standard labour market search and matching, we use stock and flow data to understand key developments. We find dramatic changes in employment, unemployment and labour market attachment in the first few months of the pandemic and a broad though gradual recovery through to the end of 2021.
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This study aims to determine the effect of environmental strategy on dynamic capabilities based on digital literacy and the performance of marketing innovations for micro, small and medium enterprises. Digital literacy-based dynamic capabilities consist of two important components, namely marketing competencies and research and development competencies. The nature of this research is explanatory where the number of research samples is micro, small and medium enterprises that have used information technology with a total number of respondents as many as 200 micro, small and medium enterprises which are divided proportionally to seven regions in Indonesia with the sampling method using accidental sampling method. The data analysis technique used SEM analysis with the help of AMOS software. The results showed that environmental strategy had no significant effect on marketing competence. Environmental strategy has a significant effect on the direction of a positive relationship to research and development competencies and has a significant effect on the direction of a positive relationship on the marketing innovation performance of micro, small and medium enterprises. Marketing competence and research and development competence have a significant effect with a positive direction of relationship to the marketing innovation performance of micro, small and medium enterprises. Research and development competence has a significant effect on the direction of a positive relationship to the marketing performance of micro, small and medium enterprises.
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Deepening the development of digital inclusive finance, dredging the impact of digital inclusive finance on the innovation path of small and medium-sized enterprises (SMEs), and strengthening financial supervision and government support are of great significance to promoting the technological innovation of SMEs. This paper selects listed companies on the New Third Board as research samples and analyzes and empirically tests the relationship between digital inclusive financial and technological innovation of small and medium-sized enterprises. The results show that digital inclusive finance can significantly promote the technological innovation level of SMEs, especially the higher the degree of digitalization, the more obvious the promotion effect. Upon further testing, it was more pronounced in the sample of high-tech industries and eastern SMEs. Digital inclusive finance can effectively alleviate the financing constraints of SMEs, thereby promoting the technological innovation of SMEs. Reasonable financial supervision and adaptive government subsidies have a positive regulating effect on the innovation incentive effect of digital inclusive finance.